Abstract
In order to determine the mechanism of action of a new AVP(4-9) analog, NC-1900, on memory processes, memory retention and retrieval tests were conducted in a step-through passive avoidance (PA) task in mice. The administration of NC-1900 facilitated memory retention and retrieval in the PA task through vasopressin1A (V1A) receptors but not V2 receptors. The effect of NC-1900 on memory retention test performance appeared to be due to activation of the protein kinase C (PKC) signaling pathway via V1A receptors; however, the modulation of PKC was not essential for the facilitative effect of the new peptide in the retrieval test. The facilitation of memory retrieval by NC-1900 may also be mediated by other non-PKC-dependent signaling pathways, such as the phospholipase C-inositol trisphosphate pathway.
MeSH terms
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Animals
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Antidiuretic Hormone Receptor Antagonists
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Arginine Vasopressin / analogs & derivatives*
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Arginine Vasopressin / pharmacology
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Enzyme Activators / administration & dosage
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Enzyme Activators / pharmacology
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Male
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Memory / drug effects*
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Mental Recall / drug effects*
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Mice
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Mice, Inbred Strains
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Oligopeptides / administration & dosage
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Oligopeptides / pharmacology*
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Phorbol Esters / pharmacology
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Piperidines / pharmacology
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Protein Kinase C / antagonists & inhibitors
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Protein Kinase C / metabolism
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Pyrrolidonecarboxylic Acid / administration & dosage
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Pyrrolidonecarboxylic Acid / analogs & derivatives*
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Pyrrolidonecarboxylic Acid / pharmacology*
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Receptors, Vasopressin / metabolism
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Stimulation, Chemical
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Antidiuretic Hormone Receptor Antagonists
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Enzyme Activators
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NC 1900
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Oligopeptides
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Phorbol Esters
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Piperidines
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Receptors, Vasopressin
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Arginine Vasopressin
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NPC 15437
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4-O-methyl-phorbol-12,13-didecanoate
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Protein Kinase C
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Tetradecanoylphorbol Acetate
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Pyrrolidonecarboxylic Acid