Identification of a new HLA-DRB1 allele in three members of an Italian family

Tissue Antigens. 2004 Aug;64(2):210-2. doi: 10.1111/j.1399-0039.2004.00262.x.

Abstract

Abstract A new human leucocyte antigen (HLA)-DRB1 allele, HLA-DRB1*1149, has been identified in three members of an Italian family during routine sequence based typing. This new allele differs from HLA-DRB1*110101 only for a single nucleotide substitution at position 113 of exon 2 resulting in an amino acid change from Valine (GTG) to Alanine (GCG) at codon 38.

MeSH terms

  • Alleles*
  • Amino Acid Sequence
  • Amino Acid Substitution
  • Base Sequence
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Italy
  • Molecular Sequence Data
  • Sequence Alignment

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*11:01:01 antigen

Associated data

  • GENBANK/AY172512