Psammaplysin C: a new cytotoxic dibromotyrosine-derived metabolite from the marine sponge Druinella (= Psammaplysilla) purpurea

J Nat Prod. 1992 Jun;55(6):822-3. doi: 10.1021/np50084a021.

Abstract

The new, cytotoxic dibromotyrosine-derived metabolite psammaplysin C [3], in addition to the two known psammaplysins A [1] and B [2], was isolated from the marine sponge Druinella purpurea. All three compounds were found to possess moderate in vitro cytotoxicity towards the human colon tumor cell-line HCT116.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Colonic Neoplasms / drug therapy
  • Porifera / chemistry*
  • Spiro Compounds / isolation & purification
  • Spiro Compounds / pharmacology*
  • Tumor Cells, Cultured / drug effects
  • Tyrosine / analogs & derivatives*
  • Tyrosine / isolation & purification
  • Tyrosine / pharmacology

Substances

  • Antineoplastic Agents
  • Spiro Compounds
  • psammaplysin C
  • Tyrosine