Antimicrobial susceptibility patterns and macrolide resistance genes of beta-hemolytic streptococci in Korea

Antimicrob Agents Chemother. 2004 Jul;48(7):2716-8. doi: 10.1128/AAC.48.7.2716-2718.2004.

Abstract

In 540 beta-hemolytic streptococci, the rates of resistance to tetracycline, chloramphenicol, erythromycin, and clindamycin were 80.0, 22.8, 20.2, and 19.1%, respectively. Of the erythromycin-resistant isolates, 63.3% had the constitutive macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype, 23.9% had the M phenotype, and 12.8% had the inducible MLS(B) resistance phenotype. The constitutive MLS(B) resistance phenotype with the erm(B) gene was dominant in Korea.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial
  • Erythromycin / pharmacology
  • Genes, Bacterial / genetics
  • Genotype
  • Humans
  • Korea / epidemiology
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Phenotype
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / genetics*
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Erythromycin