Abstract
The synthesis and pharmacological evaluation of a series of amide derivatives of NSAIDs with L-cysteine ethyl ester is described. The novel derivatives are potent antiinflammatory, antioxidant and hypocholesterolemic-hypolipidemic agents, while they demonstrate considerably reduced gastrointestinal toxicity. This molecular modification may offer a general route to safer antiinflammatory agents, potentially suitable for chronic use in conditions such as neurodegenerative disorders.
MeSH terms
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Amides / adverse effects
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Amides / chemical synthesis
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Amides / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antioxidants / adverse effects
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Antioxidants / chemical synthesis
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Antioxidants / pharmacology*
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Cholesterol / blood
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Cholesterol / metabolism
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Cysteine / analogs & derivatives*
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Cysteine / chemistry*
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Drug Evaluation
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Gastrointestinal Diseases / chemically induced*
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Lipoproteins, LDL / blood
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Lipoproteins, LDL / metabolism
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Mice
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Rats
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Triglycerides / blood
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Triglycerides / metabolism
Substances
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Amides
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Lipoproteins, LDL
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Triglycerides
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ethyl cysteine
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Cholesterol
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Cysteine