Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity

Nucleosides Nucleotides Nucleic Acids. 2004;23(4):701-14. doi: 10.1081/NCN-120037749.

Abstract

Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Dimerization
  • Fungal Proteins / chemistry*
  • HIV Infections / drug therapy
  • HIV Infections / virology
  • HIV-1 / drug effects
  • HIV-2 / drug effects
  • Humans
  • Lipase / chemistry*
  • Stavudine / chemical synthesis*
  • Stavudine / pharmacology
  • Virus Replication / drug effects
  • Zidovudine / chemical synthesis*
  • Zidovudine / pharmacology

Substances

  • Anti-HIV Agents
  • Fungal Proteins
  • Zidovudine
  • Stavudine
  • Lipase
  • lipase B, Candida antarctica