Abstract
Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology
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Cell Line
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Dimerization
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Fungal Proteins / chemistry*
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HIV Infections / drug therapy
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HIV Infections / virology
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HIV-1 / drug effects
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HIV-2 / drug effects
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Humans
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Lipase / chemistry*
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Stavudine / chemical synthesis*
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Stavudine / pharmacology
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Virus Replication / drug effects
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Zidovudine / chemical synthesis*
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Zidovudine / pharmacology
Substances
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Anti-HIV Agents
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Fungal Proteins
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Zidovudine
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Stavudine
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Lipase
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lipase B, Candida antarctica