Abstract
2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemistry*
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Analgesics / pharmacology*
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Animals
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Dose-Response Relationship, Drug
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Male
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Mice
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Monoterpenes / chemistry*
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Monoterpenes / pharmacology*
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Organoselenium Compounds / chemistry*
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Organoselenium Compounds / pharmacology*
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Pain Measurement / drug effects*
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Pain Measurement / methods
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Selenium Compounds / chemistry*
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Selenium Compounds / pharmacology*
Substances
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2-phenylselenenyl-1,8-cineole
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Analgesics
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Monoterpenes
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Organoselenium Compounds
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Selenium Compounds