Antinociceptive profile of 2-phenylselenenyl-1,8-cineole in mice

Biol Pharm Bull. 2004 Jun;27(6):910-1. doi: 10.1248/bpb.27.910.

Abstract

2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / chemistry*
  • Analgesics / pharmacology*
  • Animals
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Monoterpenes / chemistry*
  • Monoterpenes / pharmacology*
  • Organoselenium Compounds / chemistry*
  • Organoselenium Compounds / pharmacology*
  • Pain Measurement / drug effects*
  • Pain Measurement / methods
  • Selenium Compounds / chemistry*
  • Selenium Compounds / pharmacology*

Substances

  • 2-phenylselenenyl-1,8-cineole
  • Analgesics
  • Monoterpenes
  • Organoselenium Compounds
  • Selenium Compounds