Abstract
In the following three sections, we will briefly review the seminal roles of the HIV-1 nucleocapsid protein p7 (NCp7) in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase (RT) in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus.
Copyright 2004 Elsevier B.V.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Capsid Proteins / physiology*
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DNA Replication
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DNA, Viral / biosynthesis*
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Gene Products, gag / physiology*
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Genetic Variation
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HIV Long Terminal Repeat
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HIV-1 / genetics*
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HIV-1 / metabolism
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Molecular Chaperones / metabolism*
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Molecular Sequence Data
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Nucleocapsid Proteins
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RNA, Transfer, Lys / chemistry
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RNA, Transfer, Lys / genetics
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RNA, Transfer, Lys / metabolism
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Recombination, Genetic
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Viral Proteins / physiology*
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gag Gene Products, Human Immunodeficiency Virus
Substances
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Capsid Proteins
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DNA, Viral
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Gene Products, gag
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Molecular Chaperones
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NCP7 protein, Human immunodeficiency virus 1
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Nucleocapsid Proteins
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RNA, Transfer, Lys
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Viral Proteins
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gag Gene Products, Human Immunodeficiency Virus