Combating bioterrorism with personal computers

W Graham Richards; Guy H Grant; Karl N Harrison

doi:10.1016/j.jmgm.2004.03.007

Combating bioterrorism with personal computers

J Mol Graph Model. 2004 Jul;22(6):473-8. doi: 10.1016/j.jmgm.2004.03.007.

Authors

W Graham Richards¹, Guy H Grant, Karl N Harrison

Affiliation

¹ Central Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QH, UK. graham.richards@chemistry.ox.ac.uk

PMID: 15182806
DOI: 10.1016/j.jmgm.2004.03.007

Abstract

Using personal computers in a grid is permitting the in silico screening of millions of molecules to seek out potential inhibitors of agents that pose bioterror threats. Current projects are targeting anthrax and smallpox, but the approach has many attractions for investigating any known protein target and its inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Anthrax / prevention & control
Bioterrorism / prevention & control*
Computational Biology / methods*
DNA Topoisomerases, Type I / chemistry
Drug Design*
Humans
Microcomputers*
Models, Theoretical
Molecular Sequence Data
Protein Structure, Tertiary
Sequence Alignment
Smallpox / prevention & control

Substances

DNA Topoisomerases, Type I