Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Nial J Wheate; Anthony I Day; Rodney J Blanch; Alan P Arnold; Carleen Cullinane; J Grant Collins

doi:10.1039/b404358h

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Chem Commun (Camb). 2004 Jun 21:(12):1424-5. doi: 10.1039/b404358h. Epub 2004 May 18.

Authors

Nial J Wheate¹, Anthony I Day, Rodney J Blanch, Alan P Arnold, Carleen Cullinane, J Grant Collins

Affiliation

¹ School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Northcott Drive, Campbell, ACT, 2600, Australia.

PMID: 15179496
DOI: 10.1039/b404358h

Abstract

The dinuclear platinum complex trans-[[Pt(NH(3))(2)Cl](2)micro-dpzm](2+)(di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Bridged-Ring Compounds / chemistry*
DNA, Neoplasm / chemistry
DNA, Neoplasm / drug effects
Imidazoles / chemistry*
Inhibitory Concentration 50
Kinetics
Leukemia / drug therapy*
Magnetic Resonance Spectroscopy
Organoplatinum Compounds / chemistry*
Organoplatinum Compounds / pharmacology
Organoplatinum Compounds / therapeutic use
Rats
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Bridged-Ring Compounds
DNA, Neoplasm
Imidazoles
Organoplatinum Compounds
cucurbit(6)uril