Antibodies to dorsal root ganglia and olfactory cells in a patient with chronic sensory neuropathy and anosmia

Simona Gambelli; Federica Ginanneschi; Alessandro Malandrini; Silvia Palmeri; Gianna Berti; Passali Desiderio; Bellussi Luisa; Passali Francesco Maria; Alessandro Rossi

doi:10.1016/j.jns.2004.02.019

Antibodies to dorsal root ganglia and olfactory cells in a patient with chronic sensory neuropathy and anosmia

J Neurol Sci. 2004 Jun 15;221(1-2):105-8. doi: 10.1016/j.jns.2004.02.019.

Authors

Simona Gambelli¹, Federica Ginanneschi, Alessandro Malandrini, Silvia Palmeri, Gianna Berti, Passali Desiderio, Bellussi Luisa, Passali Francesco Maria, Alessandro Rossi

Affiliation

¹ Department of Neurological and Behavioural Sciences, University of Siena, Viale Bracci 2, 53100 Siena, Italy.

PMID: 15178223
DOI: 10.1016/j.jns.2004.02.019

Abstract

We report the case of a 51-year-old woman with anosmia and chronic sensory ataxic neuropathy. Olfactory tests suggested neurosensory anosmia. Immunocytochemical analysis showed serum antibodies against dorsal root ganglion (DRG) cells and olfactory neurons, in the absence of other known causes of anosmia and sensory neuropathy. Clinical and laboratory data suggested a slow autoimmune process affecting dorsal root ganglion and olfactory cells.

Publication types

Case Reports

MeSH terms

Antibodies / blood*
Ataxia / immunology
Female
Ganglia, Spinal / immunology*
Humans
Middle Aged
Nerve Fibers, Myelinated / pathology
Olfaction Disorders / complications
Olfaction Disorders / immunology*
Olfactory Nerve / immunology*
Polyradiculoneuropathy / complications
Polyradiculoneuropathy / immunology*
Sural Nerve / pathology

Substances

Antibodies