Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3555-8. doi: 10.1016/j.bmcl.2004.04.019.

Abstract

We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Animals
  • Benzodioxoles
  • Cells, Cultured
  • Chagas Disease / drug therapy
  • Dose-Response Relationship, Drug
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Inhibitory Concentration 50
  • Parasitic Sensitivity Tests
  • Piperidines / chemistry*
  • Piperidines / isolation & purification
  • Piperidines / pharmacology
  • Polyunsaturated Alkamides
  • Trypanocidal Agents / chemistry*
  • Trypanocidal Agents / isolation & purification
  • Trypanocidal Agents / pharmacology
  • Trypanosoma cruzi / drug effects*
  • Trypanosoma cruzi / growth & development

Substances

  • Alkaloids
  • Benzodioxoles
  • Piperidines
  • Polyunsaturated Alkamides
  • Trypanocidal Agents
  • piperine