The sessile and mobile macrobenthos on artificial hard bottoms was studied in 12 stations of the Sacca di Goro lagoon, a brackish, highly stressed water basin in the delta of the river Po, open to the Northwestern Adriatic Sea. Three sampling surveys were carried out in June and September 2000 and June 2001 in order to make three types of temporal comparisons: (i) on a seasonal scale, before and after a summer dystrophic event; (ii) on an annual basis, before and after the works of excavation of a canal through the outer sand bank; (iii) on a multiannual scale, comparing the data with those of a survey carried out in 1988. The biocoenoses did not show large fluctuations after a moderately severe summer dystrophic crisis, while the digging of the canal caused clear changes in the macrobenthos community structure after one year. The long-term comparison showed a shift in the community patterns after a decade.