Intravenous immunoglobulin: a safe option for treatment of steroid-resistant rejection in the presence of infection

Transplantation. 2004 May 15;77(9):1455-6. doi: 10.1097/01.tp.0000122415.08639.53.

Abstract

Management of recurrent allograft rejection is a risky proposition, especially in the presence of infections. Both steroids and antibody therapy worsen the infection risk. We successfully treated steroid-resistant rejection with intravenous immunoglobulin (IVIG) in two patients who had concomitant infections. IVIG should be considered the treatment of choice for management of steroid-resistant rejection in the presence of serious infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cytomegalovirus Infections / complications*
  • Drug Resistance
  • Escherichia coli Infections / complications*
  • Graft Rejection / complications
  • Graft Rejection / therapy*
  • Humans
  • Immunoglobulins, Intravenous*
  • Kidney Transplantation*
  • Male
  • Steroids / therapeutic use

Substances

  • Immunoglobulins, Intravenous
  • Steroids