What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

Karina R B Bastos; Claudio R F Marinho; Renato Barboza; Momtchilo Russo; José M Alvarez; Maria Regina D'Império Lima

doi:10.1016/j.micinf.2004.02.012

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

Microbes Infect. 2004 May;6(6):630-6. doi: 10.1016/j.micinf.2004.02.012.

Authors

Karina R B Bastos¹, Claudio R F Marinho, Renato Barboza, Momtchilo Russo, José M Alvarez, Maria Regina D'Império Lima

Affiliation

¹ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, Brazil. krbastos@usp.br

PMID: 15158199
DOI: 10.1016/j.micinf.2004.02.012

Abstract

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigen-Presenting Cells / immunology*
Antigen-Presenting Cells / metabolism*
Dendritic Cells / immunology*
Humans
Interleukin-12 / immunology
Interleukin-12 / physiology*
Interleukin-23
Interleukin-23 Subunit p19
Interleukins / immunology
Interleukins / physiology*
Macrophage Activation
Macrophages / immunology*
Signal Transduction

Substances

IL23A protein, human
Interleukin-23
Interleukin-23 Subunit p19
Interleukins
Interleukin-12