Immunopharmacology of CpG oligodeoxynucleotides and ribavirin

Antimicrob Agents Chemother. 2004 Jun;48(6):2314-7. doi: 10.1128/AAC.48.6.2314-2317.2004.

Abstract

To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Chemokines / biosynthesis
  • Cytokines / biosynthesis
  • DNA-Binding Proteins / agonists*
  • Humans
  • Immunity, Cellular / drug effects*
  • NF-kappa B / drug effects
  • Oligonucleotides / pharmacology*
  • Receptors, Cell Surface / agonists*
  • Ribavirin / pharmacology*
  • Signal Transduction / drug effects
  • Th1 Cells / drug effects*
  • Th1 Cells / immunology*
  • Th1 Cells / metabolism
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism
  • Toll-Like Receptor 9
  • Transfection

Substances

  • Adjuvants, Immunologic
  • Antiviral Agents
  • Chemokines
  • Cytokines
  • DNA-Binding Proteins
  • NF-kappa B
  • Oligonucleotides
  • Receptors, Cell Surface
  • TLR9 protein, human
  • Toll-Like Receptor 9
  • Ribavirin