Abstract
To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.
MeSH terms
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Adjuvants, Immunologic / pharmacology*
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Antiviral Agents / pharmacology*
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Cells, Cultured
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Chemokines / biosynthesis
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Cytokines / biosynthesis
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DNA-Binding Proteins / agonists*
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Humans
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Immunity, Cellular / drug effects*
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NF-kappa B / drug effects
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Oligonucleotides / pharmacology*
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Receptors, Cell Surface / agonists*
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Ribavirin / pharmacology*
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Signal Transduction / drug effects
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Th1 Cells / drug effects*
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Th1 Cells / immunology*
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Th1 Cells / metabolism
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Th2 Cells / drug effects
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Th2 Cells / metabolism
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Toll-Like Receptor 9
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Transfection
Substances
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Adjuvants, Immunologic
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Antiviral Agents
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Chemokines
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Cytokines
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DNA-Binding Proteins
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NF-kappa B
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Oligonucleotides
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Receptors, Cell Surface
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TLR9 protein, human
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Toll-Like Receptor 9
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Ribavirin