Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity

J Inorg Biochem. 2004 Jun;98(6):969-76. doi: 10.1016/j.jinorgbio.2004.02.012.

Abstract

6A,6B-Dideoxy-6A,6B-di[(N-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N(')-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalase / chemistry
  • Cyclodextrins / chemical synthesis
  • Cyclodextrins / chemistry*
  • Ethylenediamines / chemistry*
  • Ligands
  • Manganese / chemistry*
  • Manganese Compounds / chemistry*
  • Organometallic Compounds
  • Superoxide Dismutase / chemistry*

Substances

  • Cyclodextrins
  • Ethylenediamines
  • Ligands
  • Manganese Compounds
  • Organometallic Compounds
  • Manganese
  • N,N'-bis(salicylideneamino)ethane-manganese(II)
  • disalicylaldehyde ethylenediamine
  • Catalase
  • Superoxide Dismutase