Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp

Xiao-Chun Huang; Di Zhao; Yue-Wei Guo; Hou-Ming Wu; Li-Ping Lin; Zhong-Hua Wang; Jian Ding; Yong-Shui Lin

doi:10.1016/j.bmcl.2004.04.029

Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3117-20. doi: 10.1016/j.bmcl.2004.04.029.

Authors

Xiao-Chun Huang¹, Di Zhao, Yue-Wei Guo, Hou-Ming Wu, Li-Ping Lin, Zhong-Hua Wang, Jian Ding, Yong-Shui Lin

Affiliation

¹ State key laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Zhangjiang High-Tech Park, Shanghai 201203, China.

PMID: 15149656
DOI: 10.1016/j.bmcl.2004.04.029

Abstract

A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC(50) of 0.21 and 0.23 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / isolation & purification
Alkenes / pharmacology
Animals
Cell Line, Tumor
Cytotoxins / isolation & purification*
Cytotoxins / pharmacology*
Dinoflagellida*
HL-60 Cells
Humans
Pyrans / isolation & purification
Pyrans / pharmacology

Substances

Alkenes
Cytotoxins
Pyrans