Rett syndrome is a neurological disorder resulting from an X-linked dominant mutation. It is characterized by a variety of physical and perceptual disabilities, resulting in a need for constant therapy programs to be administered on a regular basis throughout life. Resistance to physical activity has driven the authors in a search for new intervention techniques which might improve the ability to cope while reducing difficulty in handling an external physical facilitator. Snoezelen, or multi-sensory environment, can provide a soothing environment appealing to the child or adolescent with Rett syndrome while at the same time improving physical abilities. The article reviews Rett syndrome typical phenotype and suggests suitable activities that might take place in the multi-sensory environment.