Selagoline, a new alkaloid from Huperzia selago

Dan Staerk; Jesper Larsen; Line A Larsen; Elin S Olafsdottir; Matthias Witt; Jerzy W Jaroszewski

doi:10.1080/14786410310001620600

Selagoline, a new alkaloid from Huperzia selago

Nat Prod Res. 2004 Jun;18(3):197-203. doi: 10.1080/14786410310001620600.

Authors

Dan Staerk¹, Jesper Larsen, Line A Larsen, Elin S Olafsdottir, Matthias Witt, Jerzy W Jaroszewski

Affiliation

¹ Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

PMID: 15143827
DOI: 10.1080/14786410310001620600

Abstract

A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland. Their structures were determined using 600 and 800MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Possible role of selagoline as a precursor of 5,15-oxidolycopodane, a component of the classical alkaloids L28 and L31, is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / isolation & purification*
Huperzia / chemistry*
Magnetic Resonance Spectroscopy
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Spectroscopy, Fourier Transform Infrared

Substances

Alkaloids
Cholinesterase Inhibitors
Sesquiterpenes
selagoline
serratidine
huperzine A