Abstract
Administration of 3 mg/kg 5-hydroxytryptamine2A/2C (5-HT2A/2C) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) induced c-Fos expression in all areas of the rat neocortex. The single footshock 24 h before DOI administration significantly attenuated DOI-induced c-Fos expression in layer IV of the primary somatosensory cortex. These changes in c-Fos expression suggest an adaptational change in the somatosensory cortex by acute stress.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amphetamines / pharmacology*
-
Analysis of Variance
-
Animals
-
Brain / anatomy & histology
-
Brain / drug effects*
-
Brain / metabolism
-
Brain / radiation effects
-
Cell Count / methods
-
Electroshock
-
Foot / innervation
-
Foot / radiation effects*
-
Immunohistochemistry / methods
-
Male
-
Proto-Oncogene Proteins c-fos / metabolism*
-
Rats
-
Rats, Sprague-Dawley
-
Serotonin 5-HT2 Receptor Agonists*
-
Serotonin Receptor Agonists / pharmacology*
Substances
-
Amphetamines
-
Proto-Oncogene Proteins c-fos
-
Serotonin 5-HT2 Receptor Agonists
-
Serotonin Receptor Agonists
-
4-iodo-2,5-dimethoxyphenylisopropylamine