Single footshock attenuates c-Fos expression induced by 5-HT2A receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in rat brain

Brain Res. 2004 Jun 11;1011(1):129-34. doi: 10.1016/j.brainres.2004.02.071.

Abstract

Administration of 3 mg/kg 5-hydroxytryptamine2A/2C (5-HT2A/2C) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) induced c-Fos expression in all areas of the rat neocortex. The single footshock 24 h before DOI administration significantly attenuated DOI-induced c-Fos expression in layer IV of the primary somatosensory cortex. These changes in c-Fos expression suggest an adaptational change in the somatosensory cortex by acute stress.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamines / pharmacology*
  • Analysis of Variance
  • Animals
  • Brain / anatomy & histology
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / radiation effects
  • Cell Count / methods
  • Electroshock
  • Foot / innervation
  • Foot / radiation effects*
  • Immunohistochemistry / methods
  • Male
  • Proto-Oncogene Proteins c-fos / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin 5-HT2 Receptor Agonists*
  • Serotonin Receptor Agonists / pharmacology*

Substances

  • Amphetamines
  • Proto-Oncogene Proteins c-fos
  • Serotonin 5-HT2 Receptor Agonists
  • Serotonin Receptor Agonists
  • 4-iodo-2,5-dimethoxyphenylisopropylamine