Synthesis and evaluation of oxazaborolidines for antibacterial activity against Streptococcus mutans

Adel Jabbour; Doron Steinberg; Valery M Dembitsky; Arieh Moussaieff; Batia Zaks; Morris Srebnik

doi:10.1021/jm049899b

Synthesis and evaluation of oxazaborolidines for antibacterial activity against Streptococcus mutans

J Med Chem. 2004 May 6;47(10):2409-10. doi: 10.1021/jm049899b.

Authors

Adel Jabbour¹, Doron Steinberg, Valery M Dembitsky, Arieh Moussaieff, Batia Zaks, Morris Srebnik

Affiliation

¹ Department of Medicinal Chemistry and Natural Products, School of Pharmacy, and Faculty of Dentistry, Institute of Dental Sciences, Hebrew University, Jerusalem 91120, Israel.

PMID: 15115381
DOI: 10.1021/jm049899b

Abstract

Several representative oxazaborolidines have been synthesized and evaluated against S. mutans for antibacterial activity. This is the first reported antibacterial activity of this class of compounds. The minimal inhibitory concentration values ranged from 0.53 to 6.75 mM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Boron Compounds / chemical synthesis*
Boron Compounds / chemistry
Boron Compounds / pharmacology
Heterocyclic Compounds, 1-Ring / chemical synthesis*
Heterocyclic Compounds, 1-Ring / chemistry
Heterocyclic Compounds, 1-Ring / pharmacology
Microbial Sensitivity Tests
Stereoisomerism
Streptococcus mutans / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Boron Compounds
Heterocyclic Compounds, 1-Ring