Abstract
Chemotherapy with TS-1 has recently become the first-line chemotherapy for recurrent and unresectable gastric cancer in Japan. Therefore, the establishment of a second-line chemotherapy is needed for cases that show resistance and aberrant effect to TS-1. In this study, 7 patients were treated with weekly administrations of paclitaxel after TS-1 treatment. We assessed the therapeutic effect and feasibility of chemotherapy with weekly administration of paclitaxel. Our results showed that weekly administration of paclitaxel could be a promising regimen as a second-line chemotherapy after TS-1.
MeSH terms
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Aged
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Antimetabolites, Antineoplastic / pharmacology
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Antineoplastic Agents, Phytogenic / adverse effects
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Drug Administration Schedule
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Drug Combinations
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Drug Resistance, Neoplasm
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Edema / chemically induced
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Feasibility Studies
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Female
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Humans
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Infusions, Intravenous
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Leukopenia / chemically induced
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Liver Neoplasms / secondary
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Male
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Middle Aged
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Neoplasm Recurrence, Local / drug therapy*
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Oxonic Acid / pharmacology
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Paclitaxel / administration & dosage*
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Paclitaxel / adverse effects
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Pyridines / pharmacology
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Tegafur / pharmacology
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Drug Combinations
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Pyridines
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S 1 (combination)
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Tegafur
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Oxonic Acid
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Paclitaxel