Natural product glycorandomization

Bioorg Med Chem. 2004 Apr 1;12(7):1577-84. doi: 10.1016/j.bmc.2003.12.046.

Abstract

glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.

Publication types

  • Review

MeSH terms

  • Carbohydrate Sequence
  • Catalysis
  • Galactokinase / chemistry*
  • Galactokinase / metabolism
  • Glucosyltransferases / chemistry*
  • Glucosyltransferases / metabolism
  • Glycosylation
  • Molecular Sequence Data
  • Molecular Structure
  • Nucleotidyltransferases / chemistry*
  • Nucleotidyltransferases / metabolism
  • Technology, Pharmaceutical*

Substances

  • Glucosyltransferases
  • glucosyltransferase E
  • Galactokinase
  • Nucleotidyltransferases
  • glucose-1-phosphate thymidylyltransferase