Abstract
glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.
MeSH terms
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Carbohydrate Sequence
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Catalysis
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Galactokinase / chemistry*
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Galactokinase / metabolism
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Glucosyltransferases / chemistry*
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Glucosyltransferases / metabolism
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Glycosylation
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Molecular Sequence Data
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Molecular Structure
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Nucleotidyltransferases / chemistry*
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Nucleotidyltransferases / metabolism
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Technology, Pharmaceutical*
Substances
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Glucosyltransferases
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glucosyltransferase E
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Galactokinase
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Nucleotidyltransferases
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glucose-1-phosphate thymidylyltransferase