Abstract
Mineralization of erythromycin A was studied using two differently (14)C-labeled erythromycins A, which were added to aquaculture sediment samples obtained from the two salmon hatchery sites in Washington state. The added erythromycin A did not significantly alter the numbers of the total viable colonies and erythromycin-resistant bacteria. Erythromycin-resistant Pseudomonas species contained a constitutive erythromycin esterase activity contributing to the inactivation of biologically active erythromycin A in aquatic and sediment environments. The initial rate of mineralization of erythromycin A appeared to be governed by the rate of release of soil-sorbed erythromycin A. After a prolonged lag time, the S-curves of erythromycin A mineralization were observed probably because of the increase in the population density metabolizing it. This study suggests that erythromycin A is partially or completely mineralized by the sediment microbial populations.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Aquaculture
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Biodegradation, Environmental
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Carbon Radioisotopes / metabolism
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Carboxylic Ester Hydrolases / metabolism
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Colony Count, Microbial
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Drug Resistance, Bacterial
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Erythromycin / chemistry
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Erythromycin / metabolism*
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Erythromycin / pharmacology
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Fresh Water / microbiology
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Geologic Sediments / microbiology*
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / growth & development
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Gram-Negative Bacteria / isolation & purification
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Gram-Negative Bacteria / metabolism*
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Kinetics
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Molecular Structure
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Pseudomonas / drug effects
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Pseudomonas / growth & development
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Pseudomonas / isolation & purification
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Pseudomonas / metabolism
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Soil Microbiology*
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Water Microbiology*
Substances
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Anti-Bacterial Agents
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Carbon Radioisotopes
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Erythromycin
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Carboxylic Ester Hydrolases
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erythromycin esterase