Synthesis of benzophenone oxime analogues as inhibitor of secretory phospholipase A(2) with anti-inflammatory activity

Satish Kumar Murari; Shimoga Nagaraj Sriharsha; Sheena Shashikanth; Bannikuppe Sannanaik Vishwanath

doi:10.1016/j.bmcl.2004.03.019

Synthesis of benzophenone oxime analogues as inhibitor of secretory phospholipase A(2) with anti-inflammatory activity

Bioorg Med Chem Lett. 2004 May 17;14(10):2423-5. doi: 10.1016/j.bmcl.2004.03.019.

Authors

Satish Kumar Murari¹, Shimoga Nagaraj Sriharsha, Sheena Shashikanth, Bannikuppe Sannanaik Vishwanath

Affiliation

¹ Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore 570006, India.

PMID: 15109625
DOI: 10.1016/j.bmcl.2004.03.019

Abstract

The title compound have been synthesized and tested for structure activity relationship for Phospholipase A(2) (PLA(2)) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA(2) enzyme inhibitory activity of benzophenone oxime analogue and in vivo anti-inflammatory activity studies using mice are highlighted.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / pharmacology
Benzophenones
Disease Models, Animal
Edema / drug therapy
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Inflammation / drug therapy
Mice
Oximes / chemical synthesis
Oximes / pharmacology*
Phospholipases A / antagonists & inhibitors*
Phospholipases A / metabolism
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Benzophenones
Enzyme Inhibitors
Oximes
benzophenone
Phospholipases A