Abstract
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Antiviral Agents / pharmacology
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Conserved Sequence
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Cytomegalovirus / drug effects
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Cytomegalovirus / enzymology*
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Cytomegalovirus / genetics*
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DNA-Directed DNA Polymerase / genetics*
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Gene Deletion
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Humans
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Molecular Sequence Data
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Phenotype
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Polymorphism, Genetic / genetics
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Antiviral Agents
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DNA-Directed DNA Polymerase
Associated data
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GENBANK/AY422355
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GENBANK/AY422356
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GENBANK/AY422357
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GENBANK/AY422358
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GENBANK/AY422359
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GENBANK/AY422360
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GENBANK/AY422361
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GENBANK/AY422362
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GENBANK/AY422363
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GENBANK/AY422364
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GENBANK/AY422365
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GENBANK/AY422366
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GENBANK/AY422367
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GENBANK/AY422368
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GENBANK/AY422369
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GENBANK/AY422370
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GENBANK/AY422371
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GENBANK/AY422372
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GENBANK/AY422373
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GENBANK/AY422374
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GENBANK/AY422375
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GENBANK/AY422376
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GENBANK/AY422377