New sesquiterpene dilactones from Mikania micrantha

J Nat Prod. 2004 Apr;67(4):734-6. doi: 10.1021/np034027i.

Abstract

Four new sesquiterpene dilactones, mikamicranolide (1), 11 beta,13-dihydromikamicranolide (2), 3 alpha-hydroxy-11 beta,13-dihydrodeoxymikanolide (3), and 2 beta,3 beta-dihydroxy-11 beta,13-dihydrodeoxymikanolide (4), were isolated from the whole plants of Mikania micrantha. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 possess an unusual rearranged 12,8-germacranolide sesquiterpene skeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Mikania / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Stereoisomerism

Substances

  • Lactones
  • Sesquiterpenes