Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Mar;69(3 Pt 1):031904. doi: 10.1103/PhysRevE.69.031904. Epub 2004 Mar 15.

Abstract

We investigate a two-dimensional mapping model of a paced, isolated cardiac cell that relates the duration of the action potential to the two preceding diastolic intervals as well as the preceding action potential duration. The model displays rate-dependent restitution and hence memory. We derive a criterion for the stability of the 1:1 response pattern displayed by the model. This criterion can be written in terms of experimentally measured quantities-the slopes of restitution curves obtained via different pacing protocols. In addition, we analyze the two-dimensional mapping model in the presence of closed-loop feedback control. The control is initiated by making small adjustments to the pacing interval in order to suppress alternans and stabilize the 1:1 pattern. We find that the domain of control does not depend on the functional form of the map, and, in the general case, is characterized by a combination of the slopes. We show that the gain gamma necessary to establish control may vary significantly depending on the value of the slope of the so-called standard restitution curve (herein denoted as S12), but that the product gammaS12 stays approximately in the same range.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials*
  • Adaptation, Physiological
  • Animals
  • Arrhythmias, Cardiac / physiopathology*
  • Arrhythmias, Cardiac / therapy*
  • Biological Clocks*
  • Cardiac Pacing, Artificial*
  • Feedback
  • Heart Conduction System / physiopathology*
  • Humans
  • Models, Cardiovascular*
  • Models, Neurological*
  • Muscle Cells
  • Nonlinear Dynamics