Dimemorfan enhances acetylcholine release from rat hippocampal slices

Brain Res. 2004 May 15;1008(1):113-5. doi: 10.1016/j.brainres.2004.02.014.

Abstract

Our previous study reported that an antitussive drug, dimemorfan, attenuates cholinergic dysfunction-induced amnesia in mice and acts like a sigma1 receptor agonist. This study further showed that dimemorfan (30 microM), like the putative sigma1 receptor agonist (+)-SKF-10047 (10 microM), significantly enhanced 25 mM KCl-evoked [3H]acetylcholine release from rat hippocampal but not striatal slices, which was antagonized by a sigma1 receptor antagonist haloperidol (0.3 microM).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Acetylcholine / metabolism*
  • Animals
  • Antipsychotic Agents / pharmacology
  • Atropine / pharmacology
  • Carbachol / pharmacology
  • Cholinergic Agonists / pharmacology
  • Dopamine Agonists / pharmacology
  • Dopamine Antagonists / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Haloperidol / pharmacology
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • In Vitro Techniques
  • Male
  • Morphinans / pharmacology*
  • Muscarinic Antagonists / pharmacology
  • Phenazocine / analogs & derivatives*
  • Phenazocine / pharmacology
  • Potassium Chloride / pharmacology
  • Rats
  • Tritium / metabolism

Substances

  • Antipsychotic Agents
  • Cholinergic Agonists
  • Dopamine Agonists
  • Dopamine Antagonists
  • Morphinans
  • Muscarinic Antagonists
  • Tritium
  • dimemorfan
  • Potassium Chloride
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • SK&F 10047
  • Atropine
  • Carbachol
  • Phenazocine
  • Haloperidol
  • Acetylcholine