New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents

Aurore Perzyna; Frédérique Klupsch; Raymond Houssin; Nicole Pommery; Amélie Lemoine; Jean-Pierre Hénichart

doi:10.1016/j.bmcl.2004.01.097

New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents

Bioorg Med Chem Lett. 2004 May 3;14(9):2363-5. doi: 10.1016/j.bmcl.2004.01.097.

Authors

Aurore Perzyna¹, Frédérique Klupsch, Raymond Houssin, Nicole Pommery, Amélie Lemoine, Jean-Pierre Hénichart

Affiliation

¹ Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille, 2, rue du Professeur Laguesse, BP 83, 59006 Lille, France.

PMID: 15081041
DOI: 10.1016/j.bmcl.2004.01.097

Abstract

An assessment of structure-activity relationships associated with the new benzo[5,6]pyrrolizino[1,2-b]quinoline system displaying potent in vitro cytotoxic activity against the MCF7 cell line is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Quinolines / pharmacology*

Substances

Antineoplastic Agents
Quinolines