An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction

Sangwon Cho; Gyochang Keum; Soon Bang Kang; So-Yeop Han; Youseung Kim

doi:10.1023/b:modi.0000006812.16141.b5

An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction

Mol Divers. 2003;6(3-4):283-6. doi: 10.1023/b:modi.0000006812.16141.b5.

Authors

Sangwon Cho¹, Gyochang Keum, Soon Bang Kang, So-Yeop Han, Youseung Kim

Affiliation

¹ Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.

PMID: 15068092
DOI: 10.1023/b:modi.0000006812.16141.b5

Abstract

A facile synthetic approach to 2,5-diketopiperazines 4 by the Ugi four-center three-component reaction using commercially available dipeptides as a bifunctional component, aldehydes, and isocyanides was described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Combinatorial Chemistry Techniques
Cyanides / chemistry*
Diketopiperazines
Dipeptides / chemistry*
Molecular Structure
Piperazines / chemical synthesis*

Substances

Aldehydes
Cyanides
Diketopiperazines
Dipeptides
Piperazines