Objective: To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome.
Design: Prospective, clinical study.
Setting: University hospital.
Patient(s): Ten normal healthy men.
Intervention(s): Gonadotropin-releasing hormone (GnRH) agonist, 3.75 mg, administered monthly for 3 months.
Main outcome measure(s): Insulin action (M/I ratio).
Result(s): The M/I ratio decreased from 0.24 +/- 0.04 to 0.17 +/- 0.04 after GnRH agonist therapy.
Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.