Abstract
Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1"'-->2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Epinephrine / antagonists & inhibitors
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Epinephrine / pharmacology
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Humans
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Sympathomimetics / antagonists & inhibitors
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Sympathomimetics / pharmacology
Substances
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Drugs, Chinese Herbal
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Lignans
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Platelet Aggregation Inhibitors
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Sympathomimetics
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Epinephrine