Cytosine-substituted metalloporphyrins: receptors for recognition of nucleotides in ion-selective electrodes

Org Biomol Chem. 2004 Apr 21;2(8):1169-75. doi: 10.1039/b400880d. Epub 2004 Mar 18.

Abstract

A new series of cytosine-substituted metalloporphyrin conjugates (containing Co(II) and Zn(II) as the coordinated metals) were designed and investigated as nucleotide receptors in PVC-membrane-based ion-selective electrodes under neutral conditions. The potentiometric results indicate that these systems, in particular the Co(II)-containing complex, may be potentially useful sensors for complementary nucleotide substrates in the presence of 10 mol% tridodecylmethylammonium chloride (K(Pot.)(5'-GMP/5'-AMP)= 0.045).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biosensing Techniques*
  • Cytosine / chemistry*
  • Electrodes
  • Ions
  • Metalloporphyrins / chemistry*
  • Molecular Structure
  • Nucleotides / metabolism*
  • Polyvinyl Chloride / chemistry
  • Potentiometry
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / pharmacology

Substances

  • Ions
  • Metalloporphyrins
  • Nucleotides
  • Quaternary Ammonium Compounds
  • tridodecylmethylammonium
  • Cytosine
  • Polyvinyl Chloride