The immune response to bovine viral diarrhea virus: a constantly changing picture

Christopher C L Chase; Gamal Elmowalid; Ausama A A Yousif

doi:10.1016/j.cvfa.2003.11.004

The immune response to bovine viral diarrhea virus: a constantly changing picture

Vet Clin North Am Food Anim Pract. 2004 Mar;20(1):95-114. doi: 10.1016/j.cvfa.2003.11.004.

Authors

Christopher C L Chase¹, Gamal Elmowalid, Ausama A A Yousif

Affiliation

¹ Department of Veterinary Science, South Dakota State University, P.O. Box 2175, Brookings, SD 57007, USA. christopher_chase@sdstate.edu

PMID: 15062477
DOI: 10.1016/j.cvfa.2003.11.004

Abstract

Bovine viral diarrhea virus (BVDV) is one of the major immuno-suppressive viruses of cattle. The effect on the innate and acquired immune system is unique and results in dramatic immune dysfunction. BVDV infection also has the ability to cause persistent infection (PI) in the developing fetus. This Pl syndrome creates a requirement for high levels of BVDV immunity from vaccines to prevent these infections. BVDV vaccines and their future development continue to be an enigma in the control of BVDV.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Antibodies, Viral / biosynthesis
Antibodies, Viral / immunology
Antigens, Viral / immunology
Bovine Virus Diarrhea-Mucosal Disease / immunology*
Bovine Virus Diarrhea-Mucosal Disease / prevention & control
Bovine Virus Diarrhea-Mucosal Disease / virology*
Cattle
Diarrhea Viruses, Bovine Viral / immunology*
Immunity, Cellular
Immunity, Innate
Immunity, Maternally-Acquired
Macrophages / virology
Viral Vaccines / immunology

Substances

Antibodies, Viral
Antigens, Viral
Viral Vaccines