Genomic imprinting: CTCF protects the boundaries

Annabelle Lewis; Adele Murrell

doi:10.1016/j.cub.2004.03.026

Genomic imprinting: CTCF protects the boundaries

Curr Biol. 2004 Apr 6;14(7):R284-6. doi: 10.1016/j.cub.2004.03.026.

Authors

Annabelle Lewis¹, Adele Murrell

Affiliation

¹ Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK.

PMID: 15062124
DOI: 10.1016/j.cub.2004.03.026

Abstract

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

Publication types

Review

MeSH terms

CCCTC-Binding Factor
Chromatin / metabolism*
DNA Methylation*
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Female
Genomic Imprinting / genetics*
Humans
Male
Protein Binding
RNA, Long Noncoding
RNA, Untranslated / metabolism*
Repressor Proteins / genetics
Repressor Proteins / metabolism*

Substances

CCCTC-Binding Factor
CTCF protein, human
Chromatin
DNA-Binding Proteins
H19 long non-coding RNA
RNA, Long Noncoding
RNA, Untranslated
Repressor Proteins