CD34-reactive trichodiscoma

J Cutan Pathol. 2004 May;31(5):398-400. doi: 10.1111/j.0303-6987.2004.00202.x.

Abstract

Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described.

Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter.

Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry.

Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34+ dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, CD34 / metabolism*
  • Diagnosis, Differential
  • Facial Dermatoses / metabolism*
  • Facial Dermatoses / pathology
  • Female
  • Hair Diseases / metabolism*
  • Hair Diseases / pathology
  • Hamartoma / metabolism*
  • Hamartoma / pathology
  • Humans
  • Immunohistochemistry
  • Nose Diseases / metabolism*
  • Nose Diseases / pathology

Substances

  • Antigens, CD34