Abstract
Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemistry
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Acetals / isolation & purification*
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Acetals / pharmacology
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Ascomycota / chemistry*
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology
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Crystallography, X-Ray
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Ethylenes
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Ketones / chemistry
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Ketones / isolation & purification*
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Ketones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
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Thailand
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Zearalenone / analogs & derivatives
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Zearalenone / chemistry
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Zearalenone / pharmacology
Substances
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Acetals
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Benzofurans
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Ethylenes
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Ketones
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aigialone
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aigialospirol
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hypothemycin
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Zearalenone
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ketene