Synthesis, hypoglycemic and toxicological evaluation of new 1,2-benzisothiazolyl derivatives

P Vicini; L Amoretti; A Caretta

Synthesis, hypoglycemic and toxicological evaluation of new 1,2-benzisothiazolyl derivatives

Farmaco. 1992 Mar;47(3):265-74.

Authors

P Vicini¹, L Amoretti, A Caretta

Affiliation

¹ Istituto di Chimica Farmaceutica e Tossicologica, Università di Parma.

PMID: 1503591

Abstract

The synthesis of 1,2-benzisothiazol-3-ylguanidines, 1,2-benzisothiazol-3-ylbenzensulphonylureas and 1,2-benzisothiazol-3-ylbenzensulphonamides is described. Some of the new compounds showed moderate hypoglycemic activity but most of them caused serious acute toxic effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / metabolism
Chemical Phenomena
Chemistry, Physical
Hypoglycemic Agents / chemical synthesis*
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / toxicity
Injections, Intraperitoneal
Lethal Dose 50
Male
Rats
Rats, Inbred Strains
Thiazoles / chemical synthesis*
Thiazoles / pharmacology
Thiazoles / toxicity

Substances

Blood Glucose
Hypoglycemic Agents
Thiazoles