A note on one-sided tests with multiple endpoints

Biometrics. 2004 Mar;60(1):276-9; discussion 279-80. doi: 10.1111/j.0006-341X.2004.00159.x.

Abstract

Testing problems with multivariate one-sided alternative hypotheses are common in clinical trials with multiple endpoints. In the case of comparing two treatments, treatment 1 is often preferred if it is superior for at least one of the endpoints and not biologically inferior for the remaining endpoints. Bloch et al. (2001, Biometrics57, 1039-1047) propose an intersection-union test (IUT) for this testing problem, but their test does not utilize the appropriate multivariate one-sided test. In this note we modify their test by an alternative IUT that does utilize the appropriate one-sided test. Empirical and graphical evidence show that the proposed test is more appropriate for this testing problem.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biometry
  • Clinical Trials as Topic / statistics & numerical data
  • Endpoint Determination / statistics & numerical data
  • Humans
  • Models, Statistical*
  • Monte Carlo Method
  • Multivariate Analysis