Evolution of autosomal suppression of the sex-ratio trait in Drosophila

Genetics. 2004 Jan;166(1):265-77. doi: 10.1534/genetics.166.1.265.

Abstract

The sex-ratio trait is the production of female-biased progenies due to X-linked meiotic drive in males of several Drosophila species. The driving X chromosome (called SR) is not fixed due to at least two stabilizing factors: natural selection (favoring ST, the nondriving standard X) and drive suppression by either Y-linked or autosomal genes. The evolution of autosomal suppression is explained by Fisher's principle, a mechanism of natural selection that leads to equal proportion of males and females in a sexually reproducing population. In fact, sex-ratio expression is partially suppressed by autosomal genes in at least three Drosophila species. The population genetics of this system is not completely understood. In this article we develop a mathematical model for the evolution of autosomal suppressors of SR (sup alleles) and show that: (i). an autosomal suppressor cannot invade when SR is very deleterious in males (c < (1)/(3), where c is the fitness of SR/Y males); (ii). "SR/ST, sup/+" polymorphisms occur when SR is partially deleterious ( approximately 0.3 < c < 1); while (iii). SR neutrality (c = 1) results in sup fixation and thus in total abolishment of drive. So, surprisingly, as long as there is any selection against SR/Y males, neutral autosomal suppressors will not be fixed. In that case, when a polymorphic equilibrium exists, the average female proportion in SR/Y males' progeny is given approximately by ac + 1 - a + a (2) c + 1 (2) + 1 - 4ac /4ac, where a is the fitness of SR/ST females.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • Drosophila / genetics*
  • Drosophila Proteins / genetics*
  • Female
  • Genes, Insect*
  • Male
  • Models, Genetic
  • Polymorphism, Genetic
  • Selection, Genetic
  • Sex Ratio
  • Suppression, Genetic
  • Transcription Factors / genetics*
  • X Chromosome / genetics
  • Y Chromosome / genetics

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Transcription Factors
  • sr protein, Drosophila