Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii. II. Physico-chemical properties and structure elucidation

J Antibiot (Tokyo). 2003 Dec;56(12):1000-3. doi: 10.7164/antibiotics.56.1000.

Abstract

New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and extract of mycelium of Eupenicillium shearii F80695. The structures of melanocins were established by spectroscopic methods. They are formamide compounds. In particular, melanocin A has an isocyanide group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Butanones / chemistry*
  • Butanones / isolation & purification
  • Butanones / pharmacology
  • Cyanides / chemistry*
  • Cyanides / isolation & purification
  • Cyanides / pharmacology
  • Formamides / chemistry*
  • Formamides / isolation & purification
  • Formamides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Melanins / antagonists & inhibitors*
  • Melanins / biosynthesis
  • Molecular Structure
  • Penicillium / metabolism*

Substances

  • Butanones
  • Cyanides
  • Formamides
  • Melanins
  • melanocin A
  • melanocin B
  • melanocin C