A mechanism for the development of subepithelial deposits in a patient with type III membranoproliferative glomerulonephritis

Yoshihide Fujigaki; Naro Ohashi; Katsuhiko Yonemura; Taiki Fujimoto; Hirotaka Fukasawa; Akashi Togawa; Hiroyuki Suzuki; Hideo Yasuda; Tatsuo Yamamoto; Akira Hishida

doi:10.1111/j.1440-1797.2003.00209.x

A mechanism for the development of subepithelial deposits in a patient with type III membranoproliferative glomerulonephritis

Nephrology (Carlton). 2003 Dec;8(6):280-4. doi: 10.1111/j.1440-1797.2003.00209.x.

Authors

Yoshihide Fujigaki¹, Naro Ohashi, Katsuhiko Yonemura, Taiki Fujimoto, Hirotaka Fukasawa, Akashi Togawa, Hiroyuki Suzuki, Hideo Yasuda, Tatsuo Yamamoto, Akira Hishida

Affiliation

¹ The First Department of Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan. yf0516@hama-med.ac.jp

PMID: 15012698
DOI: 10.1111/j.1440-1797.2003.00209.x

Abstract

We report on a patient with membranoproliferative glomerulonephritis (MPGN) type III, whose repeated renal biopsies show evolution from a type I-like pattern to a type III pattern of immune complex formation over a 1-year period. Based on the development of experimental in situ immune complex glomerulonephritis, we discuss possible mechanisms for the formation of subepithelial deposits in type III MPGN with reference to an experimental in situ immune complex model of glomerulonephritis.

Publication types

Case Reports

MeSH terms

Adult
Antigen-Antibody Complex*
Capillaries / pathology
Epithelium / immunology
Epithelium / pathology
Female
Glomerulonephritis, Membranoproliferative / immunology*
Glomerulonephritis, Membranoproliferative / pathology*
Humans
Kidney / blood supply
Kidney / immunology
Kidney / pathology

Substances

Antigen-Antibody Complex