Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids

Ophthalmologica. 2004 Mar-Apr;218(2):115-9. doi: 10.1159/000076147.

Abstract

By immunohistochemistry, we investigated pepsinogen C (pepC) and apolipoprotein D (apoD) expressions in 23 basal cell (BCC) and 25 squamous cell carcinomas (SCC) of the eyelids and analyzed the possible relationship to clinicopathological parameters. A total of 3 (13%) BCC and 7 (28%) SCC stained positively for pepC, whereas 11 (47.8%) BCC and 6 (24%) SCC stained positively for apoD. No significant correlation was found between pepC and apoD expressions and patients or tumor characteristics (p > 0.05). pepC and apoD, two androgen-inducible proteins, may be expressed by BCC and SCC of the eyelids. Further studies will be necessary to determine their clinical significance.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Apolipoproteins / metabolism*
  • Apolipoproteins D
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Basal Cell / metabolism*
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Eyelid Neoplasms / metabolism*
  • Eyelid Neoplasms / pathology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Neoplasm Proteins / metabolism
  • Pepsinogen C / metabolism*
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology

Substances

  • Apolipoproteins
  • Apolipoproteins D
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Pepsinogen C