Abstract
Direct O-glycosylation of amino acids bound to TentaGel resin with a number of glycosyl trichloroacetimidate donors results in high yields. The glycosylation reaction can be easily monitored by analyzing the bead-bound amino acids with high-resolution magic angle spinning (HR-MAS) NMR. These studies pave a new way for the construction of "one-bead one-compound" O-glycopeptide libraries with standard amino acid building blocks and appropriate glycosyl trichloroacetimidate donors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides
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Amino Acids / analysis
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Amino Acids / chemical synthesis*
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Chloroacetates*
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Fluorenes / analysis
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Fluorenes / chemical synthesis*
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Fucose / chemistry
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Glycosylation
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Magnetic Resonance Spectroscopy / methods
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Molecular Conformation
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Molecular Structure
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Stereoisomerism
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Trichloroacetic Acid / chemistry
Substances
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Acetamides
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Amino Acids
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Chloroacetates
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Fluorenes
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N(alpha)-fluorenylmethyloxycarbonylamino acids
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Fucose
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Trichloroacetic Acid
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trichloroacetamide