The present work reveals the helio-geophysical factors HGF) influence on natural surroundings, human and society, health state and professional reliability of human functioning in technogenic and social systems of extreme risk. The interdisciplinary complex investigations were performed on the social-population, organismal, organ cell and molecular levels. The HGF synergistic influence on a human state and functioning and the society especially within megalopolises' non-equilibrium geo-dynamic zones was studied in details. We analyzed the HGF influence on the causes and development of instabilities in ecology-social processes and the formation of intellectual and social climate. We also worked out some recommendations on stabilizing the society development concerning the geo-space and ecology-humanitarian imperative on the threshold of the current maximum of solar activity in 2000 - 2003.