Gene mutation of thiopurine S-methyltransferase in Uygur Chinese

Eur J Clin Pharmacol. 2004 Mar;60(1):1-3. doi: 10.1007/s00228-004-0730-7. Epub 2004 Feb 20.

Abstract

Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.

Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations-G238C, G460A and A719G.

Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively.

Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • China / ethnology
  • Female
  • Gene Frequency
  • Heterozygote
  • Humans
  • Male
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Mutation
  • Pharmacogenetics / methods
  • Polymerase Chain Reaction / methods
  • White People / genetics*

Substances

  • Methyltransferases
  • thiopurine methyltransferase