Abstract
DP-b99 is a derivative of the calcium chelator BAPTA that is under development as a neuroprotectant for the potential treatment of stroke, head trauma and neurological damage associated with coronary artery bypass graft. By March 2003, phase II clinical trials in acute stroke and traumatic brain injury were ongoing.
MeSH terms
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Animals
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Brain Ischemia / drug therapy
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Clinical Trials, Phase I as Topic
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Clinical Trials, Phase II as Topic
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Coronary Artery Bypass / adverse effects
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Craniocerebral Trauma / drug therapy
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Egtazic Acid / analogs & derivatives*
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Egtazic Acid / chemistry
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Egtazic Acid / pharmacokinetics*
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Egtazic Acid / therapeutic use
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Humans
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Nervous System Diseases / drug therapy
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Nervous System Diseases / etiology
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacokinetics*
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Neuroprotective Agents / therapeutic use
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Structure-Activity Relationship
Substances
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DP-b99
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Neuroprotective Agents
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Egtazic Acid