Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains

Antimicrob Agents Chemother. 2004 Mar;48(3):1043-6. doi: 10.1128/AAC.48.3.1043-1046.2004.

Abstract

In Enterobacter aerogenes and Klebsiella pneumoniae, efflux provides efficient extrusion of antibiotics and contributes to the multidrug resistance phenotype. One of the alkoxyquinoline derivatives studied here, 2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline, restores noticeable drug susceptibility to resistant clinical strains. Analyses of energy-dependent chloramphenicol efflux indicate that this compound inhibits the efflux pump mechanism and improves the activity of structurally unrelated antibiotics on multidrug-resistant E. aerogenes and K. pneumoniae isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / metabolism*
  • Chloramphenicol / metabolism
  • Chloramphenicol / pharmacology
  • Drug Resistance, Bacterial
  • Enterobacter aerogenes / drug effects*
  • Enterobacter aerogenes / metabolism*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / metabolism*
  • Phenotype
  • Pyrrolidines / pharmacology*
  • Quinolines / pharmacology*

Substances

  • 2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline
  • Anti-Bacterial Agents
  • Pyrrolidines
  • Quinolines
  • Chloramphenicol